IRM LLC; NOVARTIS AG; LI, Xiaolin; LIU, Xiaodong; MOLTENI, Valentina; CHIANELLI, Donatella; LOREN, Jon; NABAKKA, Juliet Patent: WO2008/137794 A1, 2008 ; Location in patent: Page/Page column 31-32 ; WO 2008/137794 A1