F. HOFFMANN-LA ROCHE AG; HENDRICKS, Robert, Than; HERMANN, Johannes, Cornelius; JAIME-FIGUEROA, Saul; KONDRU, Rama, K.; LOU, Yan; LYNCH, Stephen, M.; OWENS, Timothy, D.; SOTH, Michael; YEE, Calvin, Wesley Patent: WO2011/144585 A1, 2011 ; WO 2011/144585 A1