MERCK SHARP and DOHME CORP.; CHRISTOPHER, Matthew, P.; FRADERA LLINAS, Francesc Xavier; MACHACEK, Michelle; MARTINEZ, Michelle; REUTERSHAN, Michael Hale; SHIZUKA, Manami; SUN, Binyuan; THOMPSON, Christopher Francis; TROTTER, B. Wesley; VOSS, Matthew, E.; YANG, Liping Patent: WO2014/123882 A1, 2014