AMGEN INC.; BROWN, Sean P.; DRANSFIELD, Paul; DU, Xiaohui; FU, Zice; HOUZE, Jonathan; JIAO, XianYun; LAI, SuJen; LI, An-Rong; LIU, Jiwen; MA, Zhihua; MEDINA, Julio C.; PATTAROPONG, Vatee; SHEN, Wang; VIMOLRATANA, Marc; WANG, Yingcai; WANG, Zhongyu; YU, Ming; ZHU, Liusheng Patent: WO2010/45258 A2, 2010 ; Location in patent: Page/Page column 119 ; WO 2010/045258 A2