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ALNYLAM PHARMACEUTICALS, INC.; MAIER, Martin; JAYARAMAN, Muthusamy; AKINC, Akin; MATSUDA, Shigeo; KADASAMY, Pachamuthu; RAJEEV, Kallanthottathil, G.; MANOHARAN, Muthiah Patent: WO2013/86354 A1, 2013 ;