MERCK SHARP and DOHME CORP.; SEGANISH, W. Michael; BRUMFIELD, Stephanie Nicole; LIM, Jongwon; MATASI, Julius, J.; MCELROY, William, T.; TULSHIAN, Dean, B.; LAVEY, Brian, J.; ALTMAN, Michael, D.; GIBEAU, Craig, R.; LAMPE, John William; METHOT, Joey; ZHU, Liang Patent: WO2013/66729 A1, 2013 ; Location in patent: Page/Page column 208 ; WO 2013/066729 A1