THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; GERSHENGORN, Marvin; NEUMANN, Susanne; HUANG, Wenwei; THOMAS, Craig, J. Patent: WO2011/127388 A2, 2011 ; Location in patent: Page/Page column 53-55 ; WO 2011/127388 A2