ALNYLAM PHARMACEUTICALS, INC.; MANOHARAN, Muthiah; NAIR, Jayaprakash, K.; KANDASAMY, Pachamuthu; MATSUDA, Shigeo; KELIN, Alexander, V.; JAYARAMAN, Muthusamy; RAJEEV, Kallanthottathil, G. Patent: WO2015/6740 A2, 2015