F. HOFFMANN-LA ROCHE AG; CASTANEDO, Georgette; GOLDSTEIN, David, Michael; KONDRU, Rama, K.; LUCAS, Matthew, C.; PALMER, Wylie, Solang; PRICE, Stephen; SAFINA, Brian; SAVY, Pascal, Pierre, Alexandre; SEWARD, Eileen, Mary; SUTHERLIN, Daniel, P.; SWEENEY, Zachary, Kevin Patent: WO2010/136491 A1, 2010 ; Location in patent: Page/Page column 85 ; WO 2010/136491 A1