XENON PHARMACEUTICALS INC.; SUN, Shaoyi; ZENOVA, Alla, Yurevna; CHAFEEV, Mikhail; JIA, Qi; ZHANG, Zaihui; OBALLA, Renata, Marcella Patent: WO2013/64983 A1, 2013 ; Location in patent: Page/Page column 80 ; WO 2013/064983 A1