VERTEX PHARMACEUTICALS INCORPORATED; RAMTOHUL, Yeeman, K.; DAS, Sanjoy, Kumar; CADILHAC, Caroline; REDDY, Thumkunta, Jagadeeswar; VAILLANCOURT, Louis; GALLANT, Michel; LIU, Bingcan; DIETRICH, Evelyne; VALLEE, Frederic; MARTEL, Julien; POISSON, Carl Patent: WO2014/100158 A1, 2014