ACTELION PHARMACEUTICALS LTD; BUR, Daniel; CORMINBOEUF, Olivier; CREN, Sylvaine; GRISOSTOMI, Corinna; LEROY, Xavier; RICHARD-BILDSTEIN, Sylvia Patent: WO2012/77049 A1, 2012 ; Location in patent: Page/Page column 30 ; WO 2012/077049 A1