BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BETAGERI, Rajashekhar; COOK, Brian, Nicholas; DISALVO, Darren; HARCKEN, Christian; KUZMICH, Daniel; LIU, Pingrong; LORD, John; MAO, Can; RAZAVI, Hossein Patent: WO2012/87782 A1, 2012 ; Location in patent: Page/Page column 76 ; WO 2012/087782 A1