F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; HERTEL, Cornelia; KONKAR, Anish Ashok; KUEHNE, Holger; KUHN, Bernd; MAERKI, Hans P.; WANG, Haiyan Patent: WO2012/89601 A1, 2012 ; Location in patent: Page/Page column 58-59 ; WO 2012/089601 A1