MERCK SHARP andamp;; DOHME CORP.; PASTERNAK, Alexander; SHAHRIPOUR, Aurash; TANG, Haifeng; TEUMELSAN, Nardos, H.; YANG, Lihu; ZHU, Yuping; WALSH, Shawn, P. Patent: WO2010/129379 A1, 2010 ; Location in patent: Page/Page column 58 ; WO 2010/129379 A1