VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; DURRANT, Steven, John; KNEGTEL, Ronald, Marcellus Alphonsus; VIRANI, Aniza, Nizarali; REAPER, Philip, Michael Patent: WO2011/143425 A2, 2011 ; Location in patent: Page/Page column 37; 39 ; WO 2011/143425 A2