MERCK SHARP and DOHME CORP.; MERCK SHARP and DOHME LIMITED; CHEN, Qinghao; SCOTT, Jeremy; KRSKA, Shane, W.; BAXTER, Carl; STEWART, Gavin William; TAN, Lushi; GIBB, Andrew; MALIGRES, Peter, E. Patent: WO2017/58691 A1, 2017