AMGEN INC.; MONIZ, George A.; FRIZZLE, Matthew J.; BERNARD, Charles; MARTINELLI, Michael; FAUL, Margaret; LARROW, Jay; HANSEN, Karl B.; KLINGENSMITH, Liane Patent: WO2010/8729 A2, 2010 ; Location in patent: Page/Page column 45-46 ; WO 2010/008729 A2