F. HOFFMANN-LA ROCHE AG; HENDRICKS, Robert Than; HERMANN, Johannes Cornelius; KONDRU, Rama K.; LOU, Yan; LYNCH, Stephen M.; OWENS, Timothy D.; SOTH, Michael; YEE, Calvin Wesley Patent: WO2011/144584 A1, 2011 ; Location in patent: Page/Page column 50-51 ;WO 2011/144584 A1