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氟辛克生
4-fluoro-N-[2-[4-[(2S)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-5-yl]piperazin-1-yl]ethyl]benzamide
化合物简介
Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class. Originally developed as a potential antihypertensive drug, flesinoxan was later found to possess antidepressant and anxiolytic effects in animal tests. As a result, it was investigated in several small human pilot studies for the treatment of major depressive disorder, and was found to have robust effectiveness and very good tolerability. Unfortunately however, due to \"management decisions\", the development of flesinoxan was stopped and it was not pursued any further.
基本信息
CAS:98206-10-1
中文别名:N-(2-(4-((2R)-2,3-二氢-2-(羟甲基)-1,4-苯并二恶英-5-基)-1-哌嗪基)乙基)-4-氟苯甲酰胺;
英文别名:UNII-8HV9S83FNY;
分子式:C22H26FN3O4
分子量:415.458
精确质量:415.191
Psa:74.27
Logp:1.9036
中文别名:N-(2-(4-((2R)-2,3-二氢-2-(羟甲基)-1,4-苯并二恶英-5-基)-1-哌嗪基)乙基)-4-氟苯甲酰胺;
英文别名:UNII-8HV9S83FNY;
分子式:C22H26FN3O4
分子量:415.458
精确质量:415.191
Psa:74.27
Logp:1.9036
编号系统
UNII:3V574S89E1
物化性质
密度:1.271g/cm3
沸点:635.8ºC at 760mmHg
闪点:338.3ºC
折射率:1.585
沸点:635.8ºC at 760mmHg
闪点:338.3ºC
折射率:1.585
安全信息
生产方法及用途
合成路线
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参考文献
Tetrahedron Letters, , vol. 33, # 42 p. 6287 - 6290
上游原料
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图谱
Predict 1H proton NMR
13C NMR : Predict
1H NMR : Predict






