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化合物简介

Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names \"Lorzone\", Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity,[medical citation needed] which is why the combination is not recommended. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).

基本信息

CAS:95-25-0
中文别名:氯唑沙噻;5-氯-2-苯并噁唑酮;5-氯苯骈恶唑酮;5-氯-2-苯并恶唑酮;氯苯恶唑酮;氯羟苯噁唑;5-氯-2-苯并噁唑啉酮;
英文别名:Myoflexin;chloroxazone;Chlorzoxazone (350 mg);Chlorzoxazone;Paraflex;CHLORZOXANE;CHLORZOXAZONE-D3;Biomioran;5-chloro-3H-benzooxazol-2-one;Solaxin;Myoflexine;5-Chloro-2-benzoxazolone;CHLOROXAZONE;Chlorzoxazon;5-chloro-3H-1,3-benzoxazol-2-one;5-Chlor-2-hydroxy-benzoxazol;Chlorzoxazone-13C,15N,D2;2(3H)-BENZOXAZOLONE,5-CHLORO-;2(3H)-Benzoxazolone, 5-chloro-;5-CHLOROBENZOXAZOL-2-ONE;5-CHLORO-2(3H)-BENZOXAZOLONE;5-Chloro-2-hydroxybenzoxazole;Pathorysin;5-chloro-1,3-benzoxazol-2(3H)-one;CHLOROXAZON;
分子式:C7H4ClNO2
分子量:169.565
精确质量:168.993
Psa:46.26
Logp:2.1868

编号系统

MDL号:MFCD00005717

物化性质

外观与性状:白色至灰白色结晶粉末
密度:1.486 g/cm3
熔点:191-192°C(lit.)
闪点:157.5ºC
水溶解性:0.1 g/100 mL
稳定性:Stable at room temperature in closed containers under normal storage and handling conditions.
储存条件:库房低温通风干燥,与食品原料分开存放

安全信息

RTECS号:DM5250000
安全说明:S26-S36-S24/25-S37/39
WGK Germany:3
危险类别码:R36/37/38
海关编码:2934999090
危险品标志:Xi
信号词:Warning
危险性防范说明:P261; P305 + P351 + P338
危险标志:GHS07
危险性描述:H302; H315; H319; H335

生产方法及用途

生产方法
由2-氨基-5-氯苯并噁唑为原料制得。 生化研究。医用肌肉松驰剂。
用途
生化研究。医用肌肉松驰剂。

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


13C NMR : in DMSO-d6


1H NMR : 400 MHz in DMSO-d6


Mass


IR : nujol mull


IR : KBr disc


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