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化合物简介

E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.

基本信息

CAS:88321-09-9
中文别名
英文别名:ep453;Aloxistatin;LOXISTATIN;LOXASTATIN;L-trans-epoxysuccinyl-Leu-3-methylbutylamide-ethyl ester;E-64D;
分子式:C17H30N2O5
分子量:342.431
精确质量:342.215
Psa:97.03
Logp:1.7919

编号系统

MDL号:MFCD00132883

物化性质

密度:1.102g/cm3
沸点:538ºC at 760 mmHg
闪点:279.2ºC
折射率:1.485
储存条件:-20ºC

安全信息

危险类别码:R36/37/38
危险品标志:Xi

生产方法及用途

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


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