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化合物简介

Lesinurad (brand name Zurampic, zer-AM-pik) is a urate transporter inhibitor for treating hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone. It received FDA approval on December 22, 2015. The European Commission granted a marketing authorisation valid throughout the European Union on 18 February 2016.

基本信息

CAS:878672-00-5
中文别名
英文别名:CS-1389;2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid;RDEA594;LESINURAD;
分子式:C17H14BrN3O2S
分子量:404.281
精确质量:402.999
Psa:93.31
Logp:4.2371

编号系统

UNII:09ERP08I3W

物化性质

密度:1.72±0.1g/cm3
沸点:643.7±65.0°Cat760mmHg
闪点:343.1±34.3°C
外观性状:白色-米色粉末
蒸汽压:0.0±2.0mmHgat25°C
折射率:1.776
储存条件:-20°C
水溶解性:Insuluble(1.5E-4g/L)(25ºC)

安全信息

生产方法及用途

合成路线

上游原料

下游产品

图谱

1H NMR : Predict


13C NMR : Predict


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