Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

CAS：877399-52-5
中文别名：克里唑替尼;克里唑啼尼;3-[(1R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(4-哌啶)-1H-吡唑-4-基]-2-吡啶胺;3-[(R)-1-(2,6-二氯-3-氟苯基)乙氧基]-5-[1-(哌啶-4-基)-1H-吡唑-4-基]吡啶-2-胺;
英文别名：(R)-Crizotinib;Xalkori;3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine;
分子式：C21H22Cl2FN5O
分子量：450.337
精确质量：449.119
Psa：77.99
Logp：5.9477

MDL号：MFCD12407409

密度：1.475g/cm3
沸点：599.177ºC at 760 mmHg
闪点：316.171ºC
折射率：1.673

海关编码：2933990090
危险性防范说明：P273; P280; P305 + P351 + P338
信号词：Warning
危险性描述：H317; H319; H341; H400
危险标志：GHS07, GHS08, GHS09

用途
抗肿瘤。