Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

CAS：87-11-6
中文别名：硫藤黄菌素;
英文别名：Thiolutin;3-Acetamido-5-methylpyrrolin-4-one(4,3-d)-1,2-dithiole;Acetopyrrothin;6-acetylamino-4-methyl-4H-[1,2]dithiolo[4,3-b]pyrrol-5-one;Acetopyrrothine;6-Acetamido-4-methyl-1,2-dithiolo<4,3-b>pyrrol-5(4H)-on;N-(4-Methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-acetamid;N-(4-methyl-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-acetamide;6-(Acetylamino)-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one;6-Acetamido-4-methyl-1,2-dithiolo(4,3-b)pyrrol-5(4H)-one;
分子式：C8H8N2O2S2
分子量：228.291
精确质量：228.003
Psa：107.58
Logp：1.6445

MDL号：MFCD07370147

密度：1.55g/cm3
沸点：478.6ºC at 760 mmHg
闪点：243.3ºC
折射率：1.72
储存条件：库房通风低温干燥

危险类别码：R28
危险品运输编码：UN 2811 6.1/PG 2
海关编码：2933990090
危险品标志：T+