Org 27569 is a drug which acts as a potent and selective positive allosteric modulator of the cannabinoid CB1 receptor. Studies in vitro suggest that it binds to a regulatory site on the CB1 receptor target, causing a conformational change that increases the binding affinity of CB1 agonists such as CP 55,940, while decreasing the binding affinity of CB1 antagonists or inverse agonists such as rimonabant. However while Org 27569 increases the ability of CB1 agonists to bind to the receptor, it decreases their efficacy at stimulating second messenger signalling once bound, and so in practice behaves as an insurmountable antagonist of CB1 receptor function.

CAS：868273-06-7
中文别名：盐酸毛果芸香碱;5-氯-3-乙基N-[2-(4-哌啶-1-基)苯基乙基]-1H-吲哚-2-甲酰胺;
英文别名：CS-0514;
分子式：C24H28ClN3O
分子量：409.952
精确质量：409.192
Psa：48.13
Logp：5.8024

密度：1.218g/cm3
沸点：660.3ºC at 760 mmHg
闪点：353.2ºC
折射率：1.635
储存条件：2-8ºC

危险类别码：R22
海关编码：2933990090
危险品标志：Xn