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(5R)-5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-N-(1-piperidinyl)- 4,5-dihydro-1H-pyrazole-3-carboxamide
化合物简介
Rosonabant (INN; E-6776) is a drug acting as a CB1 receptor antagonist/inverse agonist that was under investigation by Esteve as an appetite suppressant for the treatment of obesity. Development of the drug for clinical use was apparently halted shortly after the related CB1 antagonist rimonabant was discontinued, likely due to the reports of severe psychiatric adverse effects such as anxiety, depression, and suicidal ideation associated with it and with similarly-acting agents.
基本信息
CAS:861151-12-4
中文别名:
英文别名:
分子式:C21H21Cl3N4O
分子量:451.777
精确质量:450.078
Psa:47.94
Logp:5.3007
中文别名:
英文别名:
分子式:C21H21Cl3N4O
分子量:451.777
精确质量:450.078
Psa:47.94
Logp:5.3007
编号系统
UNII:7X5RY2T485
物化性质
安全信息
生产方法及用途
合成路线
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参考文献
LABORATORIOS DEL DR. ESTEVE, S.A. Patent: EP1743638 A1, 2007 ; Location in patent: Page/Page column 17 ;
上游原料
下游产品
图谱
13C NMR : Predict
1H NMR : Predict





