化学科研者一站式服务平台
化合物简介
Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. It is a major constituent of the plant Ammi visnaga, also known as Bishop's Weed. Once purified, khellin exists as colorless, odorless, bitter-tasting needle-shaped crystals and is classified as a gamma-pyrone, a furanochromone derivative. In the early 20th century, researchers searched for khellin analogs with lower toxicity and better efficacy. A number of drugs were discovered through this research, such as amiodarone and cromolyn sodium, which are used in current medical practice.
基本信息
CAS:82-02-0
中文别名:呋喃并色酮;
英文别名:5H-Furo[3,2-g][1]benzopyran-5-one, 4,9-dimethoxy-7-methyl-;5,8-dimethoxy-2-methyl-4\',5\'-furo-6,7-chromane;Kelourin;Methafrone;Corafurone;Ammivisnagen;Ammispasmin;khellin;Amicardine;Coronin;Rykellin;Visammin;
分子式:C14H12O5
分子量:260.242
精确质量:260.068
Psa:61.81
Logp:2.8648
中文别名:呋喃并色酮;
英文别名:5H-Furo[3,2-g][1]benzopyran-5-one, 4,9-dimethoxy-7-methyl-;5,8-dimethoxy-2-methyl-4\',5\'-furo-6,7-chromane;Kelourin;Methafrone;Corafurone;Ammivisnagen;Ammispasmin;khellin;Amicardine;Coronin;Rykellin;Visammin;
分子式:C14H12O5
分子量:260.242
精确质量:260.068
Psa:61.81
Logp:2.8648
编号系统
EINECS号:201-392-8
MDL号:MFCD00005007
MDL号:MFCD00005007
物化性质
外观与性状:淡黄色结晶
密度:1.301 g/cm3
沸点:482.1ºC at 760 mmHg
熔点:150-154ºC
闪点:218.8ºC
折射率:1.595
储存条件:库房通风低温干燥
密度:1.301 g/cm3
沸点:482.1ºC at 760 mmHg
熔点:150-154ºC
闪点:218.8ºC
折射率:1.595
储存条件:库房通风低温干燥
安全信息
安全说明:36/37/39-45
危险类别码:R25
海关编码:2932999099
危险品运输编码:UN 2811 6.1/PG 3
危险类别:6.1(b)
包装等级:III
危险品标志:T
危险类别码:R25
海关编码:2932999099
危险品运输编码:UN 2811 6.1/PG 3
危险类别:6.1(b)
包装等级:III
危险品标志:T
生产方法及用途
用途
生化研究。医用血管舒张剂。
生化研究。医用血管舒张剂。
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict

13C NMR : in CDCl3

1H NMR : 400 MHz in CDCl3

Mass

IR : nujol mull

IR : KBr disk
