Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.

CAS：811803-05-1
中文别名：N-[4-(1-氰基环戊基)苯基]-2-[(4-吡啶甲基)氨基]-3-吡啶甲酰胺;
英文别名：YN968D1;3-​Pyridinecarboxamide, N-​[4-​(1-​cyanocyclopentyl)​phenyl]​-​2-​[(4-​pyridinylmethyl)​amino]​-;N-(4-(1-cyanocyclopentyl)phenyl)-2-((pyridin-4-ylmethyl)amino)nicotinamide;N-[4-(1-cyanocyclopentyl)phenyl]-2-(4-pyridylmethyl)amino-3-pyridine carboxyamide;N-[4-(1-cyanocyclopentyl)phenyl]-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide;W-5938;
分子式：C24H23N5O
分子量：397.472
精确质量：397.19
Psa：90.7
Logp：4.82238

MDL号：MFCD21648511