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醋酸阿奈可他
[2-[(8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
化合物简介
Anecortave (rINN) is a novel angiogenesis inhibitor used in the treatment of the exudative (wet) form of age-related macular degeneration. Although based on a steroid nucleus, which can be derived from cortisol, it possesses little glucocorticoid activity. It will be marketed by Alcon as anecortave acetate for depot suspension under the trade name Retaane.
基本信息
CAS:7753-60-8
中文别名:乙酸阿奈可他;
英文别名:2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion;Retaane;21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione;AL-3789;2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;Anecortave acetate;Anecortave;Retaane suspension;
分子式:C23H30O5
分子量:386.481
精确质量:386.209
Psa:80.67
Logp:3.3017
中文别名:乙酸阿奈可他;
英文别名:2-((10S,13S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;21-Acetoxy-17-hydroxy-pregna-4,9(11)-dien-3,20-dion;Retaane;21-acetoxy-17-hydroxy-pregna-4,9(11)-diene-3,20-dione;AL-3789;2-((8S,10S,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;Anecortave acetate;Anecortave;Retaane suspension;
分子式:C23H30O5
分子量:386.481
精确质量:386.209
Psa:80.67
Logp:3.3017
编号系统
UNII:Y0PC411K4T
物化性质
密度:1.23g/cm3
沸点:551.8ºC at 760 mmHg
闪点:188.4ºC
折射率:1.572
沸点:551.8ºC at 760 mmHg
闪点:188.4ºC
折射率:1.572
安全信息
生产方法及用途
用途
确炎舒松A醋酸酯、肤轻松醋酸酯、氟氢可的松醋酸酯的中间体。
确炎舒松A醋酸酯、肤轻松醋酸酯、氟氢可的松醋酸酯的中间体。
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
