CHAPS is a zwitterionic surfactant used in the laboratory to solubilize biological macromolecules such as proteins. It may be synthesized from cholic acid and is zwitterionic due to its quaternary ammonium and sulfonate groups; it is structurally similar to certain bile acids, such as taurodeoxycholic acid and taurochenodeoxycholic acid. It is used as a non-denaturing solvent in the process of protein purification and is especially useful in purifying membrane proteins, which are often sparingly soluble or insoluble in aqueous solution due to their native hydrophobicity.

CAS：75621-03-3
中文别名：3-[3-(胆酰胺丙基)二甲氨基]丙磺酸内盐;3-[(3-胆固醇氨丙基)二甲基氨基]-1-丙磺酸;3-[(3-胆固醇氨丙基)二甲基氨基]-1-丙磺酸(CHAPS);3-((3-胆汁氨丙基)二甲基胺)-1-丙磺酸;3-[3-(胆酰胺丙基)二甲氨基]丙磺;
英文别名：CHAPS Solution;CHAPS;CHAPS-SOL GRADE;TREND;CHAPS ELECTROPHORESIS REAGENT;CHAPS extrapure;CHAPS,HighPurity;
分子式：C32H58N2O7S
分子量：614.877
精确质量：614.396
Psa：155.37
Logp：4.3538

MDL号：MFCD00012116

外观与性状：白色结晶粉末
密度：1.01 g/mL at 20ºC
熔点：156-158ºC
稳定性：Stable at room temperature in closed containers under normal storage and handling conditions.
储存条件：2-8ºC

安全说明：S24/25
危险类别码：R36/37/38
海关编码：2934999090
危险品标志：Xi
信号词：Danger
危险标志：GHS08
危险性描述：H360
危险性防范说明：P201; P280; P308 + P313

用途
两性表面活性剂,CHAPS 是一种非变性的zwitterionic 去垢剂、蛋白质裂解液,用于溶解膜蛋白和裂解蛋白和蛋白之间的相互作用。