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2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺
2-amino-N-[4-[5-phenanthren-2-yl-3-(trifluoromethyl)pyrazol-1-yl]phenyl]acetamide
化合物简介
OSU-03012 (AR-12) is a celecoxib derivative with anticancer and anti-microbial activity. Unlike celecoxib, OSU-03012 does not inhibit COX, but inhibits several other important enzymes instead which may be useful in the treatment of some forms of cancer, while also having antifungal activity via disruption of phosphoinositide-dependent kinase-1 activity. When combined with PDE5 inhibitors such as sildenafil or tadalafil, OSU-03012 was found to show enhanced anti-tumour, antibiotic and antiviral activity against a wide variety of organisms, with this activity thought to be mediated via inhibition of the chaperone protein BiP.
基本信息
CAS：742112-33-0
中文别名：达努塞替;
英文别名：PDK1 inhibitor AR-12;2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide;
分子式：C26H19F3N4O
分子量：460.45
精确质量：460.151
Psa：72.94
Logp：6.535
中文别名：达努塞替;
英文别名：PDK1 inhibitor AR-12;2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide;
分子式：C26H19F3N4O
分子量：460.45
精确质量：460.151
Psa：72.94
Logp：6.535
编号系统
MDL号：MFCD12912272
物化性质
密度：1.369g/cm3
沸点：683.017ºC at 760 mmHg
闪点：366.876ºC
折射率：1.649
沸点：683.017ºC at 760 mmHg
闪点：366.876ºC
折射率：1.649
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict
13C NMR : Predict
