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N-[3-[4-[4-[(环己基甲基磺酰基)氨基]丁基]哌嗪-1-基]苯基]乙酰胺
N-[3-[4-[4-(cyclohexylmethylsulfonylamino)butyl]piperazin-1-yl]phenyl]acetamide
化合物简介
Naluzotan (INN, USAN; PRX-00023) is a serotonergic drug of the phenylpiperazine class that was under investigation by EPIX Pharmaceuticals Inc for the treatment of generalized anxiety disorder and major depressive disorder. It acts as a selective and potent 5-HT1A receptor partial agonist, readily stimulating prolactin responses, though it has also been found to bind to and activate the σ receptor. Naluzotan was well tolerated in clinical trials, with more patients in the control group dropping out due to adverse effects than in the active group in one study. The most frequently reported side effect was headache in 15% of patients (compared to 10% for placebo). In addition, naluzotan demonstrated significant antidepressant and anxiolytic effects as per the HAM-D and MADRS and the HAM-A, respectively, in some trials, but in others it did not. In the end it was not found to be significantly superior enough to placebo and development was stopped.
基本信息
CAS:740873-06-7
中文别名:
英文别名:Naluzotan;UNII-LQ54E5B4EW;
分子式:C23H38N4O3S
分子量:450.638
精确质量:450.266
Psa:93.62
Logp:5.171
中文别名:
英文别名:Naluzotan;UNII-LQ54E5B4EW;
分子式:C23H38N4O3S
分子量:450.638
精确质量:450.266
Psa:93.62
Logp:5.171
编号系统
UNII:LQ54E5B4EW
物化性质
密度:1.169
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
1H NMR : Predict

13C NMR : Predict
