Safingol is a lyso-sphingolipid protein kinase inhibitor. It has the molecular formula C18H39NO2 and is a colorless solid. Medicinally, safingol has demonstrated promising anticancer potential as a modulator of multi-drug resistance and as an inducer of necrosis. The administration of safingol alone has not been shown to exert a significant effect on tumor cell growth. However, preclinical and clinical studies have shown that combining safingol with conventional chemotherapy agents such as fenretinide, vinblastine, irinotecan and mitomycin C can dramatically potentiate their antitumor effects. Currently in Phase I clinical trials, it is believed to be safe to co-administer with cisplatin.

CAS：73938-69-9
中文别名：
英文别名：DL-THREO-DIHYDROSPHINGOSINE;
分子式：C18H39NO2
分子量：301.508
精确质量：301.298
Psa：66.48
Logp：4.8485

PubChem号：24894073
MDL号：MFCD00069638

熔点：80 - 82 °C