Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. It is the primary drug used for the treatment and prevention of malignant hyperthermia, a rare, life-threatening disorder triggered by general anesthesia. It is also used in the management of neuroleptic malignant syndrome, muscle spasticity (e.g. after strokes, in paraplegia, cerebral palsy, or patients with multiple sclerosis), and 2,4-dinitrophenol poisoning.

CAS：7261-97-4
中文别名：达者仑;
英文别名：Dantroleno;1-[((5-(4-nitrophenyl)-2-furanyl)methylene)amino]-2,4-imidazolidinedione;1-[5-(4-nitro-phenyl)-furan-2-ylmethyleneamino]-imidazolidine-2,4-dione;Dantrium Intravenous;UNII-F64QU97QCR;Dantrolenum;Dantroleno [INN-Spanish];Dantrolene;Dantrium;Dantrolenum [INN-Latin];1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione;danthrolene;
分子式：C14H10N4O5
分子量：314.253
精确质量：314.065
Psa：120.73
Logp：2.5304

UNII：F64QU97QCR

密度：1.57 g/cm3
沸点：175-177ºC
折射率：1.715