Rifabutin (Rfb) is a bactericidal antibiotic drug primarily used in the treatment of tuberculosis. The drug is a semi-synthetic derivative of rifamycin S. Its effect is based on blocking the DNA-dependent RNA-polymerase of the bacteria. It is effective against Gram-positive and some Gram-negative bacteria, but also against the highly resistant mycobacteria, e.g. Mycobacterium tuberculosis, M. leprae, and M. avium intracellulare.

CAS：72559-06-9
中文别名：利福布汀(安莎霉素);利福布丁;螺哌啶利福霉素S;
英文别名：Rifabutin;4-deoxo-3,4-[2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-rifamicin S;Rifabatin;RIFABUTINE;1\',4-didehydro-1-desoxi-1,4-di-hydro-5\'-(2-methyl-propyl)-1-oxo-rifamycin;6,9-dihydro-5,17,19,21-tetrahydroxy-8,9-[2-spiro-(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo]-23-methoxy-2,4,12,16,18,20,22-heptamethyl-6-oxo-2,7-epoxypentadeca-[1,11,13]-trienimine-2H-furo[2\',3\',7,8]nafto[1,2-d]imidazolo-2,4\'-piperidine-5,10,26. (3H,9H)-trione-16-acetate;lm427;Mycobutin;Ansamycin;Ansatipine;antibioticlm427;
分子式：C46H62N4O11
分子量：847.005
精确质量：846.442
Psa：205.55
Logp：4.6468

UNII：1W306TDA6S

外观与性状：红色-紫罗兰色结晶粉末
密度：1.339g/cm3
沸点：969.589ºC at 760 mmHg
熔点：169-171ºC
闪点：540.188ºC
折射率：1.623
储存条件：Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

海关编码：2941903000