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化合物简介

Aniracetam (Draganon, Sarpul, Ampamet, Memodrin, Referan), also known as N-anisoyl-2-pyrrolidinone, is an ampakine nootropic of the racetam chemical class purported to be considerably more potent than piracetam. It is lipid-soluble and has possible cognition-enhancing effects. It has been tested in animals extensively, Alzheimer's patients, and temporarily impaired healthy subjects. It has shown potential as an anxiolytic in three clinical animal models. It is sold in Europe as a prescription drug, but it is not approved by the Food and Drug Administration for use in the United States.

基本信息

CAS:72432-10-1
中文别名:1-(4-甲氧基苯酰基)-2-吡咯烷酮;L-(4-甲氧基苯甲酰基)-2-吡咯烷酮;1-(4-甲氧基苯甲酰基)-2-吡咯烷酮;茴拉西坦;
英文别名:1-p-Anisoyl-2-pyrrolidinone;Aniracetam;1-(4-methoxybenzoyl)pyrrolidin-2-one;Ampamet;Ro 13-5057;Draganon;1-anisoyl-2-pyrrolidinone;Sarpul;1-(4-Methoxybenzoyl)-2-pyrrolidinone;
分子式:C12H13NO3
分子量:219.237
精确质量:219.09
Psa:46.61
Logp:1.3957

编号系统

UNII:5L16LKN964

物化性质

外观与性状:白色结晶或结晶粉末
密度:1.15g/mL(lit.)
沸点:126-129°C(lit.)
熔点:120°C(lit.)
闪点:118°F
折射率:n20/D 1.344(lit.)
水溶解性:Reacts
稳定性:Stable at normal temperatures and pressures.
储存条件:Keep container tightly closed.
蒸汽密度:4.9 (vs air)

安全信息

RTECS号:UY5781900
WGK Germany:2

生产方法及用途

生产方法
方法1:2-吡咯烷酮和对甲氧基苯甲酰氯在乙醚中,三乙胺存在下,于0~10℃回流3h,得茴拉西坦。 为γ内酰胺类脑功能改善剂,能通过血脑屏障作用于大脑组织,改善脑功能,提高记忆力。
用途
为γ内酰胺类脑功能改善剂,能通过血脑屏障作用于大脑组织,改善脑功能,提高记忆力。

合成路线

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图谱

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1H NMR : Predict


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