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化合物简介
Methylnitronitrosoguanidine (MNNG or MNG) is a biochemical tool used experimentally as a carcinogen and mutagen. It acts by adding alkyl groups to the O6 of guanine and O4 of thymine, which can lead to transition mutations between GC and AT. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system.
基本信息
CAS:70-25-7
中文别名:1-甲基-3-硝基-1-亚硝基胍(MNNG);1-甲基-3-硝基-1-亚硝酸胍;N-甲基-N\'-硝基-N-亚硝基胍;
英文别名:Guanidine, N-methyl-N‘-nitro-N-nitroso-;1-methyl-2-nitro-1-nitrosoguanidine;1-Methyl-3-Nitro-1-NitroSOGUANIDINE;
分子式:C2H5N5O3
分子量:147.093
精确质量:147.039
Psa:114.37
Logp:0.3295
中文别名:1-甲基-3-硝基-1-亚硝基胍(MNNG);1-甲基-3-硝基-1-亚硝酸胍;N-甲基-N\'-硝基-N-亚硝基胍;
英文别名:Guanidine, N-methyl-N‘-nitro-N-nitroso-;1-methyl-2-nitro-1-nitrosoguanidine;1-Methyl-3-Nitro-1-NitroSOGUANIDINE;
分子式:C2H5N5O3
分子量:147.093
精确质量:147.039
Psa:114.37
Logp:0.3295
编号系统
MDL号:MFCD00007034
物化性质
密度:1.764g/cm3
沸点:275.703ºC at 760 mmHg
熔点:118°C (dec.)
闪点:120.541ºC
折射率:1.641
水溶解性:Reacts violently
稳定性:Unstable. Reacts violently with water. May detonate under impact. Heat, light and moisture sensitive. May explode if stored in sealed ampules. Highly flammable. Incompatible with aqueous solutions, acids, bases, oxidizing agents, reducing agents. Alkaline
储存条件:0-6ºC
蒸汽压:0.005mmHg at 25°C
沸点:275.703ºC at 760 mmHg
熔点:118°C (dec.)
闪点:120.541ºC
折射率:1.641
水溶解性:Reacts violently
稳定性:Unstable. Reacts violently with water. May detonate under impact. Heat, light and moisture sensitive. May explode if stored in sealed ampules. Highly flammable. Incompatible with aqueous solutions, acids, bases, oxidizing agents, reducing agents. Alkaline
储存条件:0-6ºC
蒸汽压:0.005mmHg at 25°C
安全信息
RTECS号:MF4200000
安全说明:S53-S45-S61
危险类别码:R45; R20; R36/38; R51/53
海关编码:2925290090
危险品运输编码:2926
危险类别:4.1
包装等级:II
危险品标志:T; N
安全说明:S53-S45-S61
危险类别码:R45; R20; R36/38; R51/53
海关编码:2925290090
危险品运输编码:2926
危险类别:4.1
包装等级:II
危险品标志:T; N
生产方法及用途
用途
化学诱变剂及癌症研究。
化学诱变剂及癌症研究。
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict

13C NMR : in DMSO-d6

1H NMR : 400 MHz in DMSO-d6

Mass spectrum (electron ionization)

Mass

IR : KBr disc
