Amastatin, also known as 3-amino-2-hydroxy-5-methylhexanoyl-L-valyl-L-valyl-L-aspartic acid, is a naturally occurring, competitive and reversible aminopeptidase inhibitor that was isolated from Streptomyces sp. ME 98-M3. It specifically inhibits leucyl aminopeptidase, alanyl aminopeptidase (aminopeptidase M/N), bacterial leucyl aminopeptidase (Aeromonas proteolytica aminopeptidase), leucyl/cystinyl aminopeptidase (oxytocinase/vasopressinase), and, to a lesser extent, glutamyl aminopeptidase (aminopeptidase A), as well as other aminopeptidases. It does not inhibit arginyl aminopeptidase (aminopeptidase B). Amastatin has been found to potentiate the central nervous system effects of oxytocin and vasopressin in vivo. It also inhibits the degradation of met-enkephalin, dynorphin A, and other endogenous peptides.

CAS：67655-94-1
中文别名：
英文别名：AMASTATIN,STREPTOMYCES SPECIES;
分子式：C21H38N4O8
分子量：474.548
精确质量：474.269
Psa：208.15
Logp：0.9194

EINECS号：614-098-3

密度：1.228g/cm3
沸点：795.1ºC at 760 mmHg
闪点：434.7ºC
折射率：1.523

危险品标志：Xi