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化合物简介

Tianeptine (brand names Stablon, Coaxil, Tatinol, Tianeurax and Salymbra) is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.

基本信息

CAS:66981-73-5
中文别名:噻奈普汀;7-[(3-氯-6,11-二氢-6-甲基二苯并[c,f][1,2]-硫氮杂卓-11-基)-氨基]庚酸 S,S-二氧化物;噻萘普汀酸;噻奈普汀酸;
英文别名:Tianeptina;Tianeptina [inn-spanish];COAXIL;Tianeotine;Tianeptinum;
分子式:C21H25ClN2O4S
分子量:436.952
精确质量:436.122
Psa:95.09
Logp:5.7293

编号系统

EINECS号:614-004-0

物化性质

外观与性状:白色固体
密度:1.38 g/cm3
沸点:609.2ºC at 760 mmHg
熔点:129-131°C
闪点:322.2ºC
折射率:1.639

安全信息

危险品运输编码:3249
危险类别:6.1(b)
包装等级:III

生产方法及用途

生产方法
27.6g(0.16m 主要作用于5-HT系统,无兴奋,镇静,抗乙酰胆碱和心脏的毒性。用于抑郁症。
用途
主要作用于5-HT系统,无兴奋,镇静,抗乙酰胆碱和心脏的毒性。用于抑郁症。

合成路线

上游原料

下游产品

图谱

13C NMR : Predict


1H NMR : Predict


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