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化合物简介

Fosmidomycin is an antibiotic that was originally isolated from culture broths of bacteria of the genus Streptomyces. It specifically inhibits DXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. It is a structural analogue of 2-C-methyl-D-erythrose 4-phosphate. It inhibits the E. coli enzyme with a KI value of 38 nM (4), MTB at 80 nM, and the Francisella enzyme at 99 nM.

基本信息

CAS:66508-53-0
中文别名
英文别名:3-[formyl(hydroxy)amino]propylphosphonic acid;Fosmidomycin sodium salt hydrate;
分子式:C4H10NO5P
分子量:183.1
精确质量:183.03
Psa:107.88
Logp:0.0377

编号系统

物化性质

密度:1.581g/cm3
沸点:463.7ºC at 760 mmHg
闪点:234.3ºC
折射率:1.533

安全信息

海关编码:2931900090

生产方法及用途

合成路线

上游原料

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图谱

13C NMR : Predict


1H NMR : Predict


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