Heterocodeine (6-methoxymorphine) is an opiate derivative, the 6-methyl ether of morphine, and a structural isomer of codeine; it is called \"hetero-\" because it is the reverse isomer of codeine. Heterocodeine was first synthesised in 1932 and first patented in 1935. It can be made from morphine by selective methylation. Codeine is the natural mono-methyl ether, but must be metabolized for activity (that is, it is a prodrug). In contrast the semi-synthetic mono-methyl ether, heterocodeine is a direct agonist. The 3,6 methyl di-ether of morphine is thebaine.

CAS：639-47-4
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分子式：C18H21NO3
分子量：299.364
精确质量：299.152
Psa：41.93
Logp：1.7901

EINECS号：211-356-3

密度：1.34g/cm3
沸点：448.9ºC at 760mmHg
闪点：225.3ºC
折射率：1.666