Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl ether hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

CAS：637-58-1
中文别名：普莫卡因;
英文别名：4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride;Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride;
分子式：C17H28ClNO3
分子量：329.862
精确质量：329.176
Psa：30.93
Logp：3.7065

UNII：88AYB867L5

外观与性状：白色或灰白色结晶粉末
沸点：427ºC at 760 mmHg
熔点：181-183ºC
闪点：123.5ºC

RTECS号：QD8750000
安全说明：S26-S36
危险类别码：R22; R36/37/38
海关编码：2934999090
危险品标志：Xi

用途
局部麻醉药。