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  • 2,2,2-三甲基硫代乙酰胺

    2,2,2-Trimethylthioacetamide

化合物简介

2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).

基本信息

CAS:630-22-8
中文别名:2,2-二甲基硫代丙胺;
英文别名:2,2-dimethylpropanethioamide;
分子式:C5H11NS
分子量:117.213
精确质量:117.061
Psa:58.11
Logp:2.0189

编号系统

物化性质

密度:0.978g/cm3
沸点:162.1ºC at 760 mmHg
熔点:117-119ºC (ethyl acetate hexane )
闪点:51.9ºC
折射率:1.513

安全信息

生产方法及用途

合成路线

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图谱

13C NMR : Predict


1H NMR : Predict


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