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化合物简介
2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
基本信息
CAS:630-22-8
中文别名:2,2-二甲基硫代丙胺;
英文别名:2,2-dimethylpropanethioamide;
分子式:C5H11NS
分子量:117.213
精确质量:117.061
Psa:58.11
Logp:2.0189
中文别名:2,2-二甲基硫代丙胺;
英文别名:2,2-dimethylpropanethioamide;
分子式:C5H11NS
分子量:117.213
精确质量:117.061
Psa:58.11
Logp:2.0189
编号系统
物化性质
密度:0.978g/cm3
沸点:162.1ºC at 760 mmHg
熔点:117-119ºC (ethyl acetate hexane )
闪点:51.9ºC
折射率:1.513
沸点:162.1ºC at 760 mmHg
熔点:117-119ºC (ethyl acetate hexane )
闪点:51.9ºC
折射率:1.513
安全信息
生产方法及用途
合成路线
上游原料
下游产品
图谱
13C NMR : Predict

1H NMR : Predict
