Nitrotyrosine is a product of tyrosine nitration mediated by reactive nitrogen species such as peroxynitrite anion and nitrogen dioxide. Nitrotyrosine is identified as an indicator or marker of cell damage, inflammation as well as NO (nitric oxide) production. Nitrotyrosine is formed in the presence of the active metabolite NO. Generally in many disease states, oxidative stress increases the production of superoxide (O2−) and NO forming peroxynitrite (ONOO−) a destructive free radical oxidant. The production of ONOO− is capable of oxidizing several lipoproteins and of nitrating tyrosine residues in many proteins. It is difficult to determine the production of ONOO− so, usually nitrotyrosine in proteins are the detectable marker for indirectly detecting ONOO−. It is detected in large number of pathological conditions and is considered a marker of NO-dependent, reactive nitrogen species-induced nitrative stress. Nitrotyrosine is detected in biological fluids such as plasma, lung aspirants-BALF (Broncho alveolar lining fluid) and urine. Increased level of nitrotyrosine is detected in rheumatoid arthritis septic shock and coeliac disease. In all these studies nitrotyrosine was undetected in healthy subjects. Nitrotyrosine is also found in numerous other disease-affected tissues, such as the cornea in keratoconus. Peroxynitrite and/or nitrative stress may participate in the pathogenesis of diabetes

CAS：621-44-3
中文别名：间硝基酪氨酸;3-硝基-酪氨酸;
英文别名：L-3-NO2-Tyr;L-Tyrosine, 3-nitro-;3-NITRO-TYROSINE;M-NITRO-L-TYROSINE;3-Nitro-L-tyrosine;NITROTYROSINE;L-4-hydroxy-3-nitro-phenylalanine;H-3-NITRO-TYR-OH;H-M-NITRO-TYR-OH;H-3-NITRO-L-TYROSINE;
分子式：C9H10N2O5
分子量：226.186
精确质量：226.059
Psa：129.37
Logp：1.4783

MDL号：MFCD00007123

外观与性状：黄色至绿色粉末
密度：1.531 g/cm3
沸点：431.6ºC at 760 mmHg
熔点：233-235ºC (dec.)
闪点：214.8ºC
稳定性：Stable under normal temperatures and pressures.
储存条件：-15ºC

安全说明：S26-S37/39
危险类别码：R36/37/38
海关编码：2922509090
危险品标志：Xi