Ethyl methanesulfonate (EMS) is a mutagenic, teratogenic, and possibly carcinogenic organic compound with formula C3H8SO3. It produces random mutations in genetic material by nucleotide substitution; particularly by guanine alkylation. This typically produces only point mutations. It can induce mutations at a rate of 5x10−4 to 5x10−2 per gene without substantial killing. The ethyl group of EMS reacts with guanine in DNA, forming the abnormal base O-6-ethylguanine. During DNA replication, DNA polymerases that catalyze the process frequently place thymine, instead of cytosine, opposite O-6-ethylguanine. Following subsequent rounds of replication, the original G:C base pair can become an A:T pair (a transition mutation). This changes the genetic information, is often harmful to cells, and can result in disease.

CAS：62-50-0
中文别名：甲基磺酸乙酯;甲基磺酸乙酯(EMS);甲烷磺酸乙酯;
英文别名：CB 1528;ethyl methane sulfonate;ETHYL MESYLATE;rcrawastenumberu119;EMS;Ethylmesilate;Methanesulfonic acid, ethyl ester;Ethyl methanesulfonate;methanesulfonic acid ethyl ester;Half-Myleran;
分子式：C3H8O3S
分子量：124.159
精确质量：124.019
Psa：51.75
Logp：1.0633

UNII：9H154DI0UP

外观与性状：无色液体
密度：1.206g/mLat 20°C
沸点：85-86°C10mm Hg(lit.)
熔点：< 25ºC
闪点：100 °C
折射率：n20/D 1.418(lit.)
稳定性：Stable. Combustible. Incompatible with water, alkalies, oxidizing agents.
储存条件：Store in a cool, dry, well-ventilated area away from incompatible substances. Keep containers tightly closed.

RTECS号：PB2100000
安全说明：S53-S23-S36/37/39-S45
危险类别码：R46; R22; R40
WGK Germany：3
危险品运输编码：2810
危险类别：6.1
包装等级：II
危险品标志：T

生产方法
1.由硫酸二甲酯与硫代硫酸钠反应,得到的甲基磺酰氯再与乙醇酯化,即得甲基磺酸乙酯。 用作菌种诱变剂,以及有机合成和癌症的研究。
用途
用作菌种诱变剂,以及有机合成和癌症的研究。