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化合物简介
Esmirtazapine (ORG-50,081) is a drug which was under development by Organon for the treatment of insomnia and vasomotor symptoms (e.g., hot flashes) associated with menopause. Esmirtazapine is the (S)-(+)-enantiomer of mirtazapine and possesses similar overall pharmacology, including inverse agonist actions at H1 and 5-HT2 receptors and antagonist actions at α2-adrenergic receptors. As of March 2010, Merck terminated internal clinical development program for esmirtazapine, for hot flashes and insomnia, for strategic reasons.
基本信息
CAS：61337-87-9
中文别名：
英文别名：mirtazapine;(14b,S)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;(S)-(+)-MIRTAZAPINE;(S)-1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3c][2]benzazepine;(S)1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino-[2,1-a] pyrido [2,3-c] [2] benzazepin;(S)-mirtazepine;(S)-1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;
分子式：C17H19N3
分子量：265.353
精确质量：265.158
Psa：19.37
Logp：2.4818
中文别名：
英文别名：mirtazapine;(14b,S)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;(S)-(+)-MIRTAZAPINE;(S)-1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3c][2]benzazepine;(S)1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino-[2,1-a] pyrido [2,3-c] [2] benzazepin;(S)-mirtazepine;(S)-1,2,3,4,10,14b-hexahydro-2-methyl-pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;
分子式：C17H19N3
分子量：265.353
精确质量：265.158
Psa：19.37
Logp：2.4818
编号系统
UNII：4685R51V7M
物化性质
安全信息
海关编码：2933990090
