Mephenesin is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants. Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries. Its use has largely been replaced by the related drug methocarbamol, which is better absorbed; Mephenesin may be an NMDA receptor antagonist.

CAS：59-47-2
中文别名：3-(2-甲基苯氧基)-1,2-丙烷二醇;3-(2-甲基苯氧基)-1,2-丙二醇;美芬新;
英文别名：Lissenphan;3-(2-methylphenoxy)-propane-1,2-diol;1,2-Propanediol, 3-(2-methylphenoxy)-;Myodetensine;Mefenesina;Decontractil;3-o-tolyloxypropane-1,2-diol;mephenesin;3-(o-tolyloxy)-1,2-propanediol;Cresoxydiol;Lissephen;Cresodiol;Decontractyl;Anatensin;
分子式：C10H14O3
分子量：182.216
精确质量：182.094
Psa：49.69
Logp：0.727

MDL号：MFCD00004718

密度：1.152g/cm3
沸点：153ºC(4 torr)
熔点：69ºC
闪点：161.5ºC
折射率：1.545

RTECS号：TZ1225000
WGK Germany：2
危险类别码：R22; R36
海关编码：2909309090
危险品标志：Xn