Pyrimethamine (trade name Daraprim) is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and to treat Toxoplasma gondii infections, particularly when combined with the sulfonamide antibiotic sulfadiazine when treating HIV-positive individuals. It works by inhibiting folic acid metabolism via dihydrofolate reductase.

CAS：58-14-0
中文别名：乙嘧啶;2,4-二氨基-6-乙基-5-对氯苯基嘧啶;息疟定;6-乙基-5-(4-氯苯基)-2,4-嘧啶二胺;5-(4-氯苯基)-6-乙基-2,4-嘧啶联氨;
英文别名：Malacid;2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-;Daraclor;Pyrimethamine;WR 2978;4753r.p.;RP 4753;bw50-63;Malocid;
分子式：C12H13ClN4
分子量：248.711
精确质量：248.083
Psa：77.82
Logp：3.6862

MDL号：MFCD00057350

外观与性状：白色粉末
密度：1.305g/cm3
沸点：491.5ºC at 760mmHg
熔点：233-234°C
闪点：251ºC
折射率：1.655
稳定性：Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents.
储存条件：0-6ºC

RTECS号：UV8140000
危险类别码：R22
WGK Germany：3
危险品运输编码：3249
海关编码：2933990090
危险类别：6.1(b)
包装等级：III
危险品标志：Xn
危险标志：GHS07
危险性描述：H302
信号词：Warning

用途
抗疟药，临床上用于预防疟疾和休止期抗复发治疗。