S-Nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol (SNO) that plays a critical role in nitric oxide (NO) signaling and is a source of bioavailable NO. NO coexists in cells with SNOs that serve as endogenous NO carriers and donors. SNOs spontaneously release NO at different rates and can be powerful terminators of free radical chain propagation reactions, by reacting directly with ROO• radicals, yielding nitro derivatives as end products. NO is generated intracellularly by the nitric oxide synthase (NOS) family of enzymes: nNOS, eNOS and iNOS while the in vivo source of many of the SNOs is unknown. In oxygenated buffers, however, formation of SNOs is due to oxidation of NO to dinitrogen trioxide (N2O3). Some evidence suggests that both exogenous NO and endogenously derived NO from nitric oxide synthases can react with glutathione to form GSNO.

CAS：57564-91-7
中文别名：亚硝基谷胱甘肽;S-亚硝基-L-谷胱甘肽;S-亚硝基谷胱甘肽;N-(N-L-Γ-谷氨酰基-S-亚硝基-L-半胱氨酰甘氨酸;
英文别名：S-Nitroso-L-glutathione;S-NITROSOGLUTATHIONE;
分子式：C10H16N4O7S
分子量：336.322
精确质量：336.074
Psa：213.55
Logp：-0.2392

MDL号：MFCD00214341

外观与性状：粉红色粉末
密度：1.68 g/cm3
熔点：>170ºC (dec.)
储存条件：-20ºC

RTECS号：MC0558000
安全说明：S26-S36
WGK Germany：3
危险类别码：R36/37/38
海关编码：2930909090
危险品标志：Xi
危险性描述：H315; H319; H335
信号词：Warning
危险标志：GHS07
危险性防范说明：P261; P305 + P351 + P338